Efficacy of 0.074% Diclofenac Mouthwash In Pain Management of Recurrent Aphthous Ulcers

Apeksha Mainali, Dipshikha Bajracharya


Aim and ObjectivesThe aim of this study was to assess the analgesic effect of 0.074% diclofenac mouthwash in patients with aphthous ulcerations.

Materials and MethodsThe study was designed as a single-blind, placebo-controlled clinical trial. 60 patients with aphthous ulcerations were randomized to receive either diclofenac mouthwash or placebo and to rinse with 15 ml of solution thrice daily for a period of 7 days. Descriptive scale was used to assess pain. After the baseline measurement of pain was recorded on the first day of the patient’s visit, spontaneous pain was recorded on the 3rd and 7th day of treatment.

ResultsData obtained were fed to SPSS software version 17 and analyzed statistically using Descriptive analysis, Chi-square test and Paired sample T-test for group comparison. Spontaneous pain was significantly reduced by diclofenac mouthwash. P-value less than 0.05% was considered to be significant with a confidence interval of 95%. There was a significant difference between the mean values of pain intensity between case and placebo (P = 0.00).

Conclusions0.074% diclofenac mouthwash is an effective and acceptable product for symptomatic relief in all types of aphthous ulceration. 


Aphthous ulcers, benzydamine hydrochloride mouthwash, diclofenac mouth wash, pain

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