Oxidative stress and periodontitis: Cause or effect

Shilpa Trivedi, Nand Lal


Periodontitis is an inflammatory disease of the tooth supporting tissues which occurs as a response to the lipopolysacchrides released by the gram negative anaerobes present in the plaque biofilm. This article summarizes the role of reactive oxygen species, antioxidants and oxidative stress in periodontitis. It is concluded that considering the confirmable involvement of excess ROS activity and associated antioxidant depletion at local and systemic levels in periodontitis, it may be reasonable to advocate the use of antioxidants in periodontitis.


antioxidant, oxidative stress, periodontitis.

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