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Primary malignant melanoma of the head and neck is a rare tumor, accounting for less than 1% of all melanomas. Rarely, melanoma may present itself without clinically evident pigmentation. Termed amelanotic melanoma, these lesions tend to have a worse prognosis because of delayed recognition and subsequent treatment. The use of radiotherapy alone has resulted in complete or partial responses, even though in the past malignant mucosal melanoma had been considered radio-resistant. Radiotherapy may be appropriate for patients with unresectable local disease, elderly patients who are poor surgical candidates or patients who refuse surgery. Here, we report a rare case of amelanotic malignant melanoma with regional metastasis, treated by radiotherapy which had a good treatment outcome.

Amelanotic, Malignant melanoma, Radiotherapy, Regional metastasis