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Objective: Carcinoma is an uncontrolled multiplication of cells, such cell production requires to replace lost cells, that will place a strain on all normal processes and deplete normal stores, one very important component for every cell is the lipid used in its cell wall. This large scale unplanned cell production would deplete cholesterol stores and possibly manifest as a fall of lipid values. Hence the present study was carried out to evaluate changes in plasma lipid profile in patients with oral precancerous conditions and to evaluate if any relation exists between the plasma lipid level and malignant potential.

Methods: A total sample size of 56 subjects was chosen, with the study group consisting of a total of 28 patients 14 with OFS and 14 with LP. The control group consisted of 28 sex and age matched individuals, without any systemic or oral condition. The histopathological confirmation was done and the patients were recalled with a minimum of 12 hour of fasting for blood examination for complete lipid profile.

Results: The present study showed that 3 parameters (TC, HDL, LDL) of lipid profile were reduced in Oral Precancerous cases as compared to age and sex matched healthy controls.

Statistical Analysis: Mean and Standard Deviation (SD) was calculated for each group. One way ANOVA was used for multiple group comparison and student’s t test (unpaired) for group wise comparison. Diagnostic validity tests were performed using lipid values as biomarkers to differentiate different disease groups with healthy controls. For all the tests p value of 0.05 or less was used for statistical significance

Conclusion: The estimation of lipid profile can be considered as a good marker for increased cell turnover. However, this will also have to be confirmed by using a larger sample size.

Precancer, Carcinoma, Cholesterol, Lipid.