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Methicillin resistant staphylococcus aureus (MRSA) has become an important source of infections during the past 20 years. This pathogen is presently responsible for up to 61% of staphylococcus infections. Although the rate of MRSA infection in maxillofacial surgical patient is not well established; we report four cases of MRSA, hospital acquired who required prolonged hospital stay and had delayed wound healing. The infection was treated with susceptible antibiotics and all four cases recovered well. The oncology patients are definitely at a greater risk. The future control of MRSA in surgical patients should focus on effective prevention of endogenous infection. Also MRSA screening for all patients who are undergoing oncological procedures should be done routinely.