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Aim and Objectives:
The aim of this study was to assess the analgesic effect of 0.074% diclofenac mouthwash in patients
with aphthous ulcerations.
Materials and Methods:
The study was designed as a single-blind, placebo-controlled clinical trial. 60 patients with aphthous
ulcerations were randomized to receive either diclofenac mouthwash or placebo and to rinse with 15
ml of solution thrice daily for a period of 7 days. Descriptive scale was used to assess pain. After the
baseline measurement of pain was recorded on the first day of the patient’s visit, spontaneous pain
was recorded on the 3rd and 7th day of treatment.
Results:
Data obtained were fed to SPSS software version 17 and analyzed statistically using Descriptive
analysis, Chi-square test and Paired sample T-test for group comparison. Spontaneous pain was
significantly reduced by diclofenac mouthwash. P-value less than 0.05% was considered to be
significant with a confidence interval of 95%. There was a significant difference between the mean
values of pain intensity between case and placebo (P = 0.00).
Conclusions:
0.074% diclofenac mouthwash is an effective and acceptable product for symptomatic relief in all
types of aphthous ulceration.

Aphthous ulcers, benzydamine hydrochloride mouthwash, diclofenac mouth wash, pain,