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Introduction: Enteric fever which includes typhoid and paratyphoid fever is a systemic febrile illness caused by the bacteria Salmonella enterica serovar typhi and Salmonella enterica serovar paratyphi A, B and C respectively. Although the gold standard for definitive diagnosis of Enteric fever is isolation of Salmonella species in culture, the Widal test has been widely used for the diagnosis of Enteric fever, simply owing to the fact that no other sero-diagnostic test of sufficient sensitivity and specificity along with cost effectiveness has been developed till date, especially in typhoid endemic regions.
Objective: The objective of this study was to determine the seroprevalence of Enteric fever in Nepalgunj Medical College, Kohalpur, Banke.
Materials and Method: This is a descriptive hospital based study. The study was conducted at Nepalgunj Medical College, Kohalpur, Banke. In this study, a total of 378 cases of suspected Enteric fever were studied in period from 12-01-2017 to 06-07-2017.
Result: A total of 378 samples, 24 (6.34%) were positive. Out of the 378 samples, 267 (70.63%) samples were from males and 111 (29.37%) samples were from females. Most of the samples 94 (24.86%) were from 20-29 years age group and the higher positive cases which were 8 (2.12%) cases also found in this ame age group. More positive cases were observed in males 14 (3.70%) than females 10 (2.64%).
Conclusion: Enteric fever remains an important public health problem in developing countries. The proper sanitation, public health education and vaccination are the long term preventive measures to decrease or control the disease. Updated data on the incidence or prevalence of typhoid fever is essential before introducing the vaccines into regular programmed.

Enteric fever; Salmonella paratyphi; Salmonella typhi; seroprevalence; Widal test.