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Introduction: Immunoglobulins are raised in smokers and gutka chewers. IgA and IgG show significant increase in count. The present study was aimed at estimation of immunoglobulins in smokers in study population.
Objective: The objective was to assess the estimation of immunoglobulins in smokers in study population.
Materials and Method: The cross-sectional study was conducted on 120 subjects of both genders. Subjects were divided into 2 groups. Group I comprised of 60 smokers of both genders and group II comprised of sex matched control. Serum level of IgG and IgA was estimated by automated Nephelometry method.
Result: The mean level of IgG was 14.24 in group I and 7.45 in group II. The difference was significant (P< 0.05). The mean level of IgA was 3.12 in group I and 1.21 in group II. The difference was significant (P< 0.05).
Conclusion: The raised levels of IgG and IgA in smokers as compared to control group increase the possibility of detecting the lesions at early stages. Thus, the subjects with habit of smoking should be routinely assessed for IgG and IgA level.

Immunoglobulins; leukoplakia; smokers.