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Introduction: Alloplasts has been successfully utilized in periodontal regeneration with its osteoconductive effect. Platelet-rich fibrin (PRF) is a second-generation platelet concentrate, which has been found to release various growth factors, therefore, has the potential to be used as a regenerative treatment for periodontal defects.

Objective: The objective was to evaluate the effect of alloplastic bone graft material, 30% β-tricalcium phosphate and 70% Hydroxyapatite (30% β -TCP + 70% HA) with and without platelet-rich fibrin membrane (PRF membrane) in the treatment of vertical bony defects.

Materials and Method: Twenty patients (10 patients per group, one site per patient) were randomized into group A (30% β-TCP+70% HA and PRF membrane) and Group B (30% β-TCP+70% HA). Pocket depths (PD), clinical attachment levels (CAL) were recorded at baseline, three months, six months, and nine months post-operatively. Similarly, a radiographic evaluation was done at baseline, three months, six months, and nine months to evaluate the defect fill.

Result: Significant reduction in all clinical and radiographic parameters were observed in both the treatment groups. Post-surgical measurements revealed a greater reduction in PD (3.8mm), greater CAL gain (3.7mm), and greater defect fill (1.45mm) in group A as compared to group B with PD reduction (3.4 mm), CAL gain (3.2 mm) and, defect fill (1.23 mm), with no statistically significant difference between the groups.

Conclusion: PRF membrane in addition to alloplast (30% β-TCP +70% HA) did not provide additional benefit in terms of PD, CAL, and defect fill in the treatment of vertical bony defects in periodontitis patients.

Bone graft; bony defect; periodontal regeneration; platelet-rich fibrin membrane