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Introduction: Dental extraction is the most common procedure in oral surgery. It is a common model for evaluating the effectiveness of analgesics for pain relief.

Objective: To evaluate analgesic effectiveness of Ketorolac (10 mg) and Nimesulide (100 mg) in control of pain, swelling, and trismus after extractions of impacted third molar.

Materials and Method: A non-randomised trial was conducted in the Department of Oral and Maxillofacial Surgery, Kathmandu Medical College from July to September 2020 after obtaining ethical approval. Forty-two patients were divided into two treatment groups (Nimesulide and Ketorolac). The medications were given orally, immediately after extraction followed by twice a day. Pain intensity levels, trismus, and swelling were measured and compared between two groups at six, 12, 24, 48, and 72 hours post-operatively. Data collected were analysed in Statistical Package for Social Sciences v.20 using Mann-Whitney U test, Independent t test and Friedman test.

Result: There was no significant difference in between groups at different time points but identified a significant difference between time points within each group (P <0.001). The difference was significant within each group in mouth opening at different time intervals (P <0.001). Swelling was more pronounced in Nimesulide group than in the Ketorolac group.

Conclusion: Both Ketorolac 10 mg and Nimesulide 100 mg are effective anti-inflammatory and analgesic drugs after surgical extraction. There was no significant difference between two drugs in pain and mouth opening in different time periods. However, Ketorolac was observed to be more effective than Nimesulide as anti-inflammatory drug after extractions.

Keterolac; nimesulide; pain; swelling; third molar; trismus.