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Introduction: Various plaque control methods are employed in treatment of gingivitis which is plaque-induced recurring condition. However, it is also preventable and reversible. Propolis, a naturally-occurring bee product, possess variety of biological and pharmacological properties viz. anti-inflammatory, antimicrobial, antiparasitic, antiviral, immunostimulating, fungicidal, and antiulcer proving it to be helpful in wound healing.

Objective: To assess the effectiveness of Propolis mouthwash in chronic generalised gingivitis and also compare Propolis mouthwash with Chlorhexidine mouthwash among Nepali population.

Materials and Method: This non-randomised intervention study was conducted at the Department of Periodontics, KIST Medical College and Teaching Hospital from March 30, 2022 to June 14, 2022 after ethical clearance. It included 30 systemically healthy patients with chronic generalised gingivitis utilising convenience sampling technique. They were divided into two groups (15 participants in each group) and advised to use Propolis containing mouthwash and 0.2% Chlorhexidine mouthwash two times in a day. Plaque index (PI) and gingival index (GI) were assessed on Ramjford teeth at baseline and at five days interval. The level of signifi­cance was P

Result: Paired t-test analysis showed that the observed differences in PI and GI before and after using Propolis mouthwash and Chlorhexidine mouthwash were statistically significant (P <0.05). However, PI and GI between two mouthwashes did not show any sig­nificant difference.

Conclusion: Within the limitations of current study, it was observed that using Propolis mouthwash improved the gingival index and plaque index and its effect was comparable to Chlorhexidine.

Chlorhexidine; gingivitis; mouthwash; propolis.