| JNDA Vol. 22 No. 1 Issue 34 (January - June 2022) | |
Significance of Connective Tissue and Immunological Markers in Oral Submucous Fibrosis |
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| Dr. Pragya Regmee, Dr. Jyotsna Rimal, Dr. Iccha Kumar Maharjan, Dr. Apekshya Niraula, Dr. Deepa Niroula, Dr. Abhinaya Luitel | |
Download Full Article  414.91KB |
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| Abstract | |
Oral submucous fibrosis (OSF) has high malignant transformation rate. It mainly affects the South-Asian population, majorly because of areca nut consumption habit. Many biochemical markers are studied for OSF, ranging from serum iron, trace metal elements, antioxidants and many genetic markers. The ones focused in this review are immunological markers (immunoglobulins, cytokines, complement derivatives) connective tissue markers (β- Fibroblast Growth Factor (FGF), myofibroblast, α-Smooth Muscle Actin (SMA), Transforming Growth Factor-β (TGF)) and genetic predisposition (like higher expression of Sister Chromatid Exchange (SCE) and Human Leukocyte Antigen (HLA), genetic involvement of Suppressor of Mothers against Decapentaplegic (SMAD)-2, SMAD-3, SMAD-7, matrix metalloproteinase (MMP1), MMP2, MMP9, etc). Biomarkers are very useful in predicting the disease, its progression, rate of malignant transformation and prognosis. For this reason, identifying and exploring the biochemical markers of OSF is of utmost importance to reduce the mortality and morbidity associated with the disease. |
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| Keywords | |
Biomarkers; connective tissue; genetic predisposition to disease, immunology; oral submucous fibrosis. |
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