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Introduction: The risk of adverse drug reactions (ADRs) in dentistry is significant. While pharmacotherapy is crucial in treating and managing various dental diseases and conditions, there is often a lack of knowledge, positive attitude, and consistent practice regarding ADR reporting among dentists and other health personnel.

Objective: To evaluate the knowledge, attitude, and practice of dental doctors and interns about the pharmacovigilance.

Methodology: This analytical cross-sectional study was conducted from 2022 January to 2023 February. A convenient sampling method was applied requesting 384 dental professionals directly or online. Participants provided informed consent before completing a semi-structured online questionnaire. The questionnaire consisted of five sections: demographics, knowledge, attitude, practice of pharmacovigilance, and reasons for underreporting ADRs. Ethical approval was obtained, and participant identity was protected. Data were analysed using descriptive statistics (percent, frequency, median), and a p-value

Result: Only 214 (55.7%) were aware of the term pharmacovigilance and more than 90% did not know about the reporting site and ways of it. More than 85% agreed the need of it to be trained or taught to dental practitioners. But the practice of institutional reporting of ADR was very low, 240 (62.5%) had never reported the ADR.

Conclusion: These findings reveal that there is lack of knowledge and practice among Nepali Dental practitioners, while most of them are eager to learn and implement. So intervention is required to make aware and train all the practicing Dentist and incorporation of this topic in syllabus of dental schools.

Adverse drug reaction; dental; health; pharmacovigilance.